[orlistat]
For Those Who Simply Can't Lose The Weight, Taking Alli Orlistat May Help GPs tell their patients that the most effective and sustainable way to los...
For Those Who Simply Can't Lose The Weight, Taking Alli Orlistat May Help
GPs tell their patients that the most effective and sustainable way to lose weight and keep it off is through a balanced diet and regular physical activity. There's still considerable resistance to this notion from people who'd rather rely on surgery or drugs like Orlistat 120 mg to deal with their obesity.
aAll the Sibutramine in the world is not going to make a dent on our overweight population,a says Wendy Smithson, a physician in Leeds. aDrugs can be an effective part of weight loss treatment, but they cannot be the first choice. People have to eat properly and get physically active. If my patients still have a worrisome BMI months after adopting a healthy lifestyle, 'm willing to discuss other methods for getting those extra kilograms off, but not before then.a
Obesity is a leading cause of premature death in the UK, with complications from excess weight combined with inactivity significantly increasing the risk of Cardiovascular Disease, Cancers, High Blood Pressure, Stroke and Type 2 Diabetes. For individuals who are unable to return to a healthy body weight through traditional methods, what options are there? Surgery is the last resort, but are there drugs that might be effective before something so drastic has to be considered? Online Clinic UK, an online medical resource, has information on several popular medications.
Sibutramine, often found under the brand name of Reductil, is used to assist patients who are unable to lose weight through diet and exercise alone. It works by blocking specific neurotransmitters, effectively tricking patients into feeling full after eating less food than they typically would. There are potential side effects to taking Sibutramine, although in most patients they disappear after roughly a month. Usually prescribed in pill form, standard dosage is 10 mg to 15 mg per day and most physicians recommend taking the drug for no longer than one year at a time.
Orlistat 120 mg is perhaps better known as Xenical, a weight loss drug developed by GlaxoSmithKline. While many popular weight loss products act as appetite supressants, Orlistat 120 mg inhibits a digestive enzyme (a lipase) which normally breaks down dietary fat; with lipase blocked, a portion of a patient's dietary fat is not processed and is passed by the body instead. Alli or Alli Orlistat is lower dose version of Orlistat 120 mg; although only available through pharmacies, unlike Orlistat 120 mg, Alli does not require a doctor's prescription.
While exercise and a balanced diet can help most people to achieve their target BMI, it's comforting to know there are options less drastic than surgery for those who don't succeed.
How to prove Orlistat is an inhibitor for lipase?
I need to design an experiment to prove that Orlistat is an inhibitor of lipase. Do you have any suggestion on how i might start?
Well, if it’s an in vittro experiment , get some lipase (sold as pancreatic enzyme) and place lipase in 2 test tubes. Add orlistat to one and add lipids to both shake and see the results.
If it is an in vivo experiment, get several of your friends to eat a high fat meal. Give half orlistat. See the results….you’d expect smelly,fatty stools that float in the group that took orlistat and normal stools in those that didn’t.
Can I take orlistat weight loss pills if contraindicated for persons with gall bladder removal?
I have had gall bladder removed three years ago. Want to try “alli” orlistat tablets to help lose weight as BMI 33. I do not understand why they are contraindicated for this condition.
I have been prescribed Orlistat – is it safe to take when there is no gall bladder?
I have just been prescribed 125mg Orlistat. I had my gall bladder removed approx 2 years ago due to stones. I know you shouldnt take when you have or have had Cholecystitis. I had it – but I wont again as no gall bladder. Could anyone advise me please. Thanks.
Orlistat????
Hi well ive been to the docs today as my weight is getting me down, she said that i qualify to use a drug called Orlistat which works by blocking fat from being taken in to th ebody by the food you eat, I know it requires a low fat diet and i’m prepared for that i would just like to know if anyone else has used this product before and how much did you weigh before and after, also how long it took you to lose the weight????
Thanks for any reply’s.
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I have been trying to lose weight for 5 months with little or no progress, so yes she has my history and she didnt just put me straight on them, i have to go back and speak to a nurse then try and lose a bit of weight then she will prescribe them in about 4 weeks!!!!
Hi. I took Zenical a long time ago, it’s the same thing as Orlistat and they are the same as Alli. If you eat any thing fatty be prepared to have uncontrollable stinky oil leaks from your bum. It will get all over your pants big time and stain whatever you sit on. It’s nasty. Maybe for you it is worth a try, but all I got was a nasty mess and I don’t think it helped me loose any pounds, but I do admit to cheating–which led to some of the problems I had with it. But it doesn’t take but one cheat to end up with a mess.
NO DO NOT TAKE. Refer Wikipedia.
Orlistat (marketed as a prescription under the trade name Xenical by Roche in most countries, or over-the-counter as Alli[2] by GlaxoSmithKline in the United Kingdom and the United States), also known as tetrahydrolipstatin, is a drug designed to treat obesity.[3] Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. It is intended for use in conjunction with a physician-supervised reduced-calorie diet. Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini.[4] However, due to simplicity and stability, orlistat rather than lipstatin was developed into an anti-obesity drug.[5]
The effectiveness of orlistat in promoting weight loss is definite, though modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms (4.4–6.6 lb) more than those not taking the drug over the course of a year.[6] Orlistat also modestly reduces blood pressure, and appears to prevent the onset of type 2 diabetes, whether due to weight loss itself or to other effects; in a large randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly 40% in obese people.[7]
Orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). These decrease with time, however, and are the most frequently reported adverse effects of the drug
Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and are excreted undigested instead. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces.
At the standard prescription dose of 120 mg three times daily before meals, orlistat prevents approximately 30% of dietary fat from being absorbed,[9] and about 25% at the standard over-the-counter dose of 60 mg.[10][11] Higher doses do not produce more potent effects.[12]
he primary side effects of the drug are gastrointestinal-related, and include steatorrhea (oily, loose stools with excessive flatus due to unabsorbed fats reaching the large intestine), fecal incontinence and frequent or urgent bowel movements. GlaxoSmithKline recommends that all users be cautious of the possible side effects until they “have a sense of any treatment effects”.[14][15] To minimize these effects, foods with high fat content should be avoided; the manufacturer advises consumers to follow a low-fat, reduced-calorie diet. Oily stools and flatulence can be controlled by reducing the dietary fat content to somewhere in the region of 15 grams per meal.[16] The manual for Alli makes it clear that orlistat treatment involves aversion therapy, encouraging the user to associate eating fat with unpleasant treatment effects.[17]On August 24, the FDA reported that it would investigate 30 cases of liver damage reported between 1999 and October 2008 in patients taking orlistat, including six cases of liver failure.[30]
[edit]Interactions
Orlistat may reduce plasma levels of ciclosporin (also known as “cyclosporin” or “cyclosporine”, trade names Sandimmune, Gengraf, Neoral, etc.), an immunosuppressive drug frequently used to prevent transplant rejection; the two drugs should therefore not be administered concomitantly.[18] Orlistat can also impair absorption of the antiarrhythmic amiodarone.[31]
[edit]Contraindications
Orlistat is contraindicated in:[18]
Malabsorption
Hypersensitivity to orlistat
Reduced gallbladder function (e.g. after cholecystectomy)
Pregnancy and breastfeeding
Use caution with: obstructed bile duct, impaired liver function, and pancreatic disease
[edit]
How does Orlistat (Xenecol) work? Does it ihibit the digestive enzymes that would break down the fat?
I know this is random, but i have been given Orlistat and have just done about enzymes in biology. So my brain is now working overtime and i thought that maybe the orlistat is an inhibitor and this is why the fat comes out whole?
Ooooh i love that i know how things work lol!!
SO is it a non competitive inhibitor?
Orlistat is a lipase inhibitor, and it works by reducing the absorption of dietary fat. It is used in conjunction with a mildly hypocaloric diet in individuals with a body mass index (BMI) of 30 kg/m2 or more or in individuals with a BMI of 28 kg/m2 in the presence of other risk factors such as type 2 diabetes, hypertension, or hypercholesterolaemia.
It may however impair absorption of fat-soluble vitamins.
Hope this helps.
I would be really careful taking Alli because the way it blocks fat can really mess with your system if you’ve had problems like this before. I would definitely talk to your doctor if you aren’t sure. This isn’t a quick fix – it will mostly just help you to lose weight faster with a healthy diet and exercise. I don’t think it’s worth the risk for you with these past health problems.